Junyoung O. Park
EducationPrinceton University, Princeton, NJ – 2010 - 2016
University of California, San Diego (UCSD), La Jolla, CA – 2007 - 2010
EmploymentUniversity of California, Los Angeles (UCLA), Los Angeles, CA – 2018 - present
Massachusetts Institute of Technology, Cambridge, MA – 2016 - 2018
TrainingBioinformatics and Metabolic Engineering Laboratory, MIT – 2016 - 2018
Adviser: Prof. Gregory Stephanopoulos
- Developed a 13C-18O-based metabolic flux and free energy analysis framework for various cell types including bacteria and cancer cells.
- Applied the metabolic flux and free energy analysis to maximize conversion of CO2 into oil using Moorella thermoacetica and Yarrowia lipolytica.
- Characterized renal cell carcinoma metabolism under combinatorial therapeutics.
Adviser: Prof. Joshua D. Rabinowitz
- Developed a flux-based method and software to measure Gibbs free energy of metabolic reactions.
- Developed an integrative framework combining metabolite concentrations, fluxes, and thermodynamics for more precise and comprehensive characterization of metabolism.
- Applied the integrated approach to several biological systems including E. coli, yeast, Clostridium species, hepatocytes, renal epithelial cells, and in vivo mouse models to elucidate fundamental metabolic regulation, to achieve effective biofuel production, and to better understand diabetes and cancer.
- Contributed to a successful Department of Energy grant proposal.
Adviser: Prof. Shyni Varghese
- Designed and developed a small diameter hydrogel-based vascular graft that is highly biocompatible, reduces significantly the risk of thrombosis, and increases the patency once placed within patients.
- Conducted various mechanical testing and reached the final design of poly(ethylene glycol) diacrylate (PEGDA)-clay nanocomposite hydrogel, which showed robust mechanical properties that can be controlled by varying clay concentrations.
Adviser: Prof. Gaurav Arya
- Built a computer model to simulate random walks of transcription factors in the presence of various conformations of compact chromatin fibers using C++.
- Performed kinetic Monte Carlo simulation, which revealed different modes of diffusion that transcription factors undergo: 3D-diffusion, when they are far away from DNA/chromatin fiber and 1D-diffusion along the DNA, otherwise.
Adviser: Prof. Bernhard Ø. Palsson
- Developed the Biochemical, Genetic and Genomic (BiGG) knowledgebase, which provides the first collection of curated, high quality metabolic reconstructions.
- Integrated metabolic flux constraints as well as objective functions required for mathematical optimization to various organisms’ genome-scale metabolic reconstruction models.
- Rendered respective organisms’ metabolic networks in Scalable Vector Graphics (SVG) that can be interactively displayed in web browsers using Perl and SQL.
TeachingDepartment of Chemical and Biomolecular Engineering, UCLA – 2018 - present
Department of Chemical Engineering, MIT – 2017
Department of Chemical and Biological Engineering, Princeton University – 2012 - 2015
Seoul Language Institute, South Korea – 2010
Department of Physics, UCSD – 2008
- Integrating kinetics, thermodynamics, and metabolomics. Korea Institute for Advanced Study (KIAS) in Seoul, South Korea, 4/30/2019
- Integration of metabolomics and fluxomics via thermodynamics. VIB Metabolomics Data Interpretation in Leuven, Belgium, 3/11/2019
- Integrative-omics in biotechnology. ISPE Biopharmaceutical Manufacturing Conference in Huntington Beach, 12/11/2018
- Glycolysis balances enzyme efficiency, energy efficiency, and metabolic adaptivity. UCLA Metabolism Interest Group, 12/7/2018
- Systems-level engineering of metabolic networks. UCLA QCBio Retreat at Calamigos Ranch, Malibu, 9/25/2018
- Integration of metabolomics and fluxomics via thermodynamics. Pfizer in Cambridge 2018
- Systems-level engineering of metabolic networks. UCLA 2018
- Efficient energy utilization in carbon-fixing Moorella thermoacetica. AIChE Annual Meeting in Minneapolis 2017
- Park, J. O., Wei, M. H., Tanner, L. B., Amador-Noguez, D., Li, S. H., Rabinowitz, J. D. Glycolysis balances enzyme efficiency and metabolic adaptivity. Department of Energy Genomic Sciences Program Annual PI Meeting 2017
- Dash, S., Khodayari, A., Zhou, J., Holwerda, E. K., Olson, D. G., Park, J. O., Emerson, D., Woolston, B., Chen, P., Liao, J. C., Stephanopoulos, G., Lynd, L. R., Maranas, C. D. Ensemble cell-wide kinetic modeling of anaerobic organisms to support fuels and chemicals production. Department of Energy Genomic Sciences Program Annual PI Meeting 2017
- Towards integrative metabolomics in biotechnology and medicine. Y-IBS symposium at Harvard 2016
- Park, J. O., Amador-Noguez, D., Wei, M. H., Rabinowitz, J. D. Limited forward thermodynamic driving force in glycolysis of slow-growing bacteria. Department of Energy Genomic Science Contractor-Grantee Meeting XIV 2016
- Metabolite concentrations and ΔG that favor efficient enzyme usage are a conserved feature of cellular metabolism. MIT 2015
- Park, J. O., Rubin, S. A., Xu, Y. F., Amador-Noguez, D., Fan, J., Rabinowitz, J. D. Conservation of absolute cellular metabolite concentrations. Department of Energy Genomic Science Contractors-Grantees Meeting XIII 2015
- Park, J. O., Rubin, S. A., Xu, Y. F., Amador-Noguez, D., Fan, J., Rabinowitz, J. D. Comprehensive quantitation of metabolite concentrations, gross reaction fluxes, and reaction free energies across cells from four organisms. Metabolism, Diet and Disease 2014
- Amador-Noguez, D., Park, J. O., Zhang, Z., Rubin, S. A., Xu, W., Rabinowitz, J. D. A fully reversible, highly energy efficient glycolysis with unique cofactor utilization in C. cellulolyticum. Department of Energy Genomic Science Contractor-Grantee Meeting XII 2014
- Xu, Y. F., Doucette, C. D., Park, J. O., Roquet, N., Amador-Noguez, D., Reaves, M. L., Feng, X. J., Rabitz, H., Schwab, D. J., Wingreen, N. S., Rabinowitz, J. D. Integration of carbon, nitrogen, and oxygen metabolism in Escherichia coli. Department of Energy Genomic Science Awardee Meeting X 2012
- Park, J. O., Xu, Y. F., Rabinowitz, J. D. Integration of carbon, nitrogen, and oxygen metabolism in Escherichia coli. International Conference and Exhibition on Metabolomics & Systems Biology 2012
- Park, J. O., Arya G. Facilitated Diffusion of Transcription Factors in Search of DNA Target Sites. Calit2 Summer Scholars Poster Session at UCSD 2009
- Park, J. O., Schellenberger J., Conrad, T. M., Palsson, B. Ø. BiGG: Biochemical, Genetic and Genomic Database. Calit2 Summer Scholars Poster Session at UCSD 2008
- Metabolic Engineering Guest Lecture, CBE 447 04/2015
- Princeton Chemical Biology Meeting 04/2015, 06/2013
- Princeton E-ffiliates Partnership Retreat 02/2015
- Princeton Prokaryotes Meeting 03/2016, 11/2015, 10/2014, 05/2014, 10/2013, 11/2012
- Princeton BioEngineering Colloquium 03/2014
- Graduate Student Symposium 10/2013, 10/2012
HonorsHellman Fellowship – 2020
UCLA Faculty Career Development Award – 2020
Professor of the Year (AIChE at UCLA) – 2019
Schowalter Travel Fund – 2012 - 2015
Hughes Scholars Program at UCSD – 2009 - 2010
Warren College Honors Student – 2008 - 2010
Provost Honors – 2007 - 2010
Otto Schaler Scholarship – 2009
Calit2 Summer Undergraduate Research Scholarship – 2008 - 2009